For the past 6 months I’ve had this interesting mac issue - once or twice a month my internal drive which generally has about 90GB free on it would drop to 25GB free or less, I originally thought perhaps the drive was dying because rebooting off a system dvd and repairing the drive generally fixed it - about a week ago - that fix stopped working, and I thought hmm.. maybe something just isn’t cleaning up after itself - since we’re talking about 65GB I immediately thought it must be iPhoto/Photoshop/Illustrator/Fireworks since it’s pretty unlikely coda/textmate/expresso (and YES I use all three) ever use that much of anything - so I dug deeper, I have a demo of DaisyDisk hanging around that showed me my ‘CodeEquivalenceDatabase’ (which lives in: var/db) file was 64GB - it didn’t take a rocket scientist to figure out that it was likely that file was the problem - but I wasn’t sure, maybe that file was supposed to be that big - some more googling and that file is tied directly to 1password and keychain - I ran repair ‘keychain’ BOOM crashed/reboot/won’t restart/lovely - reboot again and it came back - some more googling led me to believe I could just delete ‘CodeEquivalenceDatabase’ and it would be regenerated, so I did - and it was, the new file was 16k UNTIL I launched Transmit, it seems that every time I launch Transmit the file doubles in size - I suppose that might shed some light on how often I launch Transmit (I’d love for someone to do that math).
Conclusion
I deleted Transmit and reinstalled, and the problem seems to have gone away, it’s important to mention that it’s highly unlikely this was a Transmit problem, it more likely that it was just a very ugly anomaly on my machine, I haven’t experienced anything like this on any other system.